Is the ceiling codeine dose a myth?

Anon54

Firstly, Wikipedia claims there is not ceiling dose to Codeine:

A dose of approximately 200 mg (oral) of codeine must be administered to give analgesia approximately equivalent to 30 mg (oral) of morphine (Rossi, 2004). However, codeine is, in general, not used in single doses of greater than 60 mg (and no more than 240 mg in 24 hours).[5] When analgesia beyond this is required, stronger opioids such as hydrocodone or oxycodone are favored.

Codeine is metabolized to C6G by uridine diphosphate glucuronosyl transferase UGT2B7, and, since only about 5% of codeine is metabolized by cytochrome P450 CYP2D6, the current evidence is that C6G is the primary active compound.[6] Claims about the supposed “ceiling effect” of codeine doses seemed to rest on the assumption that high doses of codeine saturated CYP2D6, which prevented further conversion of codeine to morphine, which is simply incorrect.[citation needed] There is also no evidence that CYP2D6 inhibition is useful in treating codeine dependence,[7] though the metabolism of codeine to morphine (and hence further metabolism to glucuronide morphine conjugates) does have an effect on the abuse potential of codeine.[8] However, CYP2D6 has been implicated in the toxicity and death of neonates when administered to lactating mothers, particularly those with increased 2D6 activity (“ultra-rapid” metabolisers).

Secondly, I found this source on another BL thread

I just found this, the equivalence between 4 Codeine salts:

From the stronger to the weaker:
-20mg Codeine Hydrochloride = 17,1mg Codeine
-20mg Codeine Phosphate Hemihydrate = 15,6mg Codeine
-20mg Codeine Phosphate = 14,7mg Codeine
-20mg Codeine Camsilate = 11,9mg Codeine

(I found that on a very reliable site)

So this means u would have to tae 600mg of Codeine phosphate to equals only 450mg even if 450mg is the so called ceiling dose.

Has anyone had any experiences with dosing higher han 450mg Codeine Phosphate & did they notice an increased effect?
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kokaino

Firstly, Wikipedia claims there is not ceiling dose to Codeine:

Secondly, I found this source on another BL thread

So this means u would have to tae 600mg of Codeine phosphate to equals only 450mg even if 450mg is the so called ceiling dose.

Has anyone had any experiences with dosing higher han 450mg Codeine Phosphate & did they notice an increased effect?

Different salts can produce different, I don’t want to say effects, but different lipid solubility,etc.

For example, morphine diacetate (heroin) and morphine sulfate. One is slightly more potent due to a quicker onset of morphine’s effects.

NeighborhoodThreat

Your thread (http://www.bluelight.ru/vb/showthread.php?t=569332) in AusDD is much more active, so I’m going to close this one.

Please don’t double post threads.