Anon54
My dr suggested Luvox to me. said it’s to be taken at night but i dont understand. it’s an ssri. do most ppl take this at night?
This is quoted from wiki
it says it inhibits the effect of valium. so that would mean it reduces its effect 🙁
i dont understand the part about opiod. Does it lower the effects of then or what?
Drug interactions Fluvoxamine has a low potential for the drug interactions which are based on inhibition of enzyme Cytochrome P450 CYP2D6. Fluvoxamine shows the least interaction of the SSRIs, in regard to this specific enzyme.[21][22][23] Naturally the other SSRIs which are metabolized by CYP2D6 will have more CYP2D6-based interactions with TCAs, antiarrhythmics, B-blockers, phenytoin, opioids and neuroleptics.
Fluvoxamine does, however, inhibit cytochrome P450 enzyme CYP1A2, which metabolises agomelatine, caffeine, clozapine, haloperidol, phenacetin, tacrine, theophylline, and olanzapine. These substances can cause increased serum levels when administered together with fluvoxamine. Of major concern is the fact that the polycyclic aromatic hydrocarbons found in tobacco smoke are potent inducers of CYP1A2 so that smokers may require significant modification of medication dosage.[24] A recent warning has been published regarding potentially serious interaction with tizanidine, based on CYP1A2 metabolism.[25]
Fluvoxamine inhibits metabolism of diazepam and phenytoin via CYP2C19 and metabolism of aripiprazole, chlorpromazine, clozapine, haloperidol, olanzapine, perphenazine, risperidone, thioridazine and zuclopenthixol via CYP2D6 as well as of aripiprazole, clozapine, haloperidol, quetiapine and ziprasidone via CYP3A4.[26]
The plasma protein binding of fluvoxamine is about 77%. Drugs with low protein binding are less likely to displace other protein bound drugs, and therefore have a lower potential to cause protein binding-related drug interactions.
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Johnsonville
It doesn’t inhibit Valium, it inhibits the METABOLIZATION of Valium, thus if you took valium a 10 mg dose would feel much more powerful because if you don’t metabolize it, then the drug builds up in your blood stream. The same thing goes for the Opiods and other drugs, since they can’t be metabolized as effectively after first-pass, Blood Serum Levels rise.
From what I know Trazodone is the more common SSRI prescribed for sleep-aid purposes though I’m not sure if thats why you’re taking it. A common side-effect of, at least the older SSRIs, is drowsiness so if you take it at night, it will still work in changing the plasticity of serotonin-based receptors but will take advantage of this side-effect. The newer SSRIs, or maybe more common ones, are better about not causing drowsiness but as far as I know, time of intake shouldnt matter…
Anon54
so it causes drowsiness?
i thought ALL ssris were to be taken in the morning.
the dr only suggested it. sounds pretty cool if its guess it if increases the effects of valium & opiates 😉
I think i’ll give it a miss im a but skeptical about ADs.
I didnt even like tramadol all that much cuz of its SNRI effects.
Johnsonville
I’ve tried bupropion and lexapro and hated them both. Wellbutrin gave me pretty bad social anxiety or made my existing SAD much worse. Lexapro did seem to work but the sexual side effects made me eventually go off them. I eventually got put on Vyvanse in the name of a child-hood ADD screen I took and though it is a stim, it has been great so far.
Valley88
I’ve run my course with trying SSRIs, personally. I was on Luvox for 5 months, assured by my pysch that it would work alongside my klonopin to fully treat my condition. Well after 5 months of feeling nothing at all or any better b/c of it, I quit cold turkey & am doing no worse than before I went on it, actually I’m feeling better. I know some ppl may find success with them & I hope the OP of this thread does, but I find SSRIs to be complete shit (and I’ve given several of them legit/long term tries). I swear SSRIs are like water pills (to me at least).
Honestly, getting regular exercise is 100x better for my anxiety/depression than a worthless pill like Prozac, Luvox, etc.
.. And yes they can be taken in the morning or @ night, just depends on what your pysch thinks is best suited. Lots of times they’ll break it up into morning & night doses, or just do it all in the morn or all @ night.
NeighborhoodThreat
so it causes drowsiness?
i thought ALL ssris were to be taken in the morning.
the dr only suggested it. sounds pretty cool if its guess it if increases the effects of valium & opiates
I think i’ll give it a miss im a but skeptical about ADs.
I didnt even like tramadol all that much cuz of its SNRI effects.
Not directly, it inhibits the metabolism of your Valium dosage so the Valium is probably making you more drowsy. (Because the Valium is staying in your system longer and at higher concentrations, etc..just think of it this way: Your Luvox is potentiating your Valium)
However, some SSRIs do have drowsiness as a side effect. If your doctor prescribed you to take yours at night, that’s probably why. All SSRIs affect people differently.